Code
NTG-AMEP-02BX
Profile
Active-Compendium
Client-Bill Only
Clinical
Oncology,Pathology
<p><b>Bone Marrow Aspirate:</b> 1-2 mL in EDTA tube.<br> <b>Peripheral Blood:</b> 2-3 mL in EDTA tube.<br> <b>Note on fresh samples:</b> NeoGenomics should receive within 7 days from collection for acceptable cell viability.</p>
Flag Active
True
Orderable Test Description
<p>The NEO | AML Express assay is a next-generation sequencing (NGS) assay using combined DNA- and RNA-sequencing, which is used to identify prognostically and diagnostically informative alterations in acute myeloid leukemia (AML). The DNA sequencing component of this assay detects single nucleotide variants (SNVs) and indels in genes recurrently mutated in AML, and the RNA sequencing component detects fusions involving genes that are frequently involved in structural rearrangements observed in AML, as noted below. Test reports include a summary interpretation of all results together.<br><br>
DNA (38 genes):<br>
ABL1, ASXL1, BCOR, BRAF, CALR, CBL, CEBPA, CSF3R, DDX41, DNMT3A, ETV6, EZH2, FLT3 (ITD and TKD), GATA2, HRAS, IDH1, IDH2, JAK2, KIT, KRAS, MPL, NF1, NPM1, NRAS, PHF6, PPM1D, PRPF8, PTPN11, RUNX1, SETBP1, SF3B1, SRSF2, STAG2, TET2, TP53, U2AF1, WT1, ZRSR2<br><br>
RNA (9 genes):<br>
ABL1, KAT6A, KMT2A, MECOM, MYH11, NUP214, NUP98, RARA, RUNX1</p>
DNA (38 genes):<br>
ABL1, ASXL1, BCOR, BRAF, CALR, CBL, CEBPA, CSF3R, DDX41, DNMT3A, ETV6, EZH2, FLT3 (ITD and TKD), GATA2, HRAS, IDH1, IDH2, JAK2, KIT, KRAS, MPL, NF1, NPM1, NRAS, PHF6, PPM1D, PRPF8, PTPN11, RUNX1, SETBP1, SF3B1, SRSF2, STAG2, TET2, TP53, U2AF1, WT1, ZRSR2<br><br>
RNA (9 genes):<br>
ABL1, KAT6A, KMT2A, MECOM, MYH11, NUP214, NUP98, RARA, RUNX1</p>
Orderable Turn Around Time
5 Days
Keywords
Orderable Biomarkers
NY Approved
False
Orderable Biomarkers JSON
{"DNA Sequencing": {"SNVs + Indels": ["CSF3R", "DNMT3A", "ETV6", "EZH2", "HRAS", "IDH1", "IDH2", "KIT", "CALR", "KRAS", "NPM1", "NRAS", "PHF6", "PTPN11", "PRPF8", "SETBP1", "SF3B1", "RUNX1", "STAG2", "TET2", "SRSF2", "WT1", "ZRSR2", "U2AF1", "MPL", "DDX41", "PPM1D", "NF1", "CBL", "ABL1", "FLT3", "JAK2", "GATA2", "TP53", "ASXL1", "BCOR", "BRAF", "CEBPA"]}, "RNA Sequencing": {"Fusions": ["KAT6A", "RARA", "MYH11", "ABL1", "KMT2A", "NUP98", "MECOM", "RUNX1", "NUP214"]}}
Keywords string
AML NGS, AML diagnosis, acute myeloid leukemia NGS, acute myeloid leukemia diagnosis, rapid AML, rapid acute myeloid leukemia, AML NEO AML Express
Title URL
neo-aml-express
Clinical Significance
In conjunction with clinical features and other laboratory results, molecular profiling with the NEO Express AML panel may facilitate risk stratification and therapy selection for patients with newly diagnosed AML.
Storage and transportation
Refrigerate specimen. Do not freeze. Use cold pack for transport, making sure cold pack is not in direct contact with specimen. Important! To ensure fast TAT and sample stability, ship samples directly to NeoGenomics Houston.