Code
NTG-PTCX-02CX
Profile
Active-Compendium
81450x1
81479
Clinical
Oncology,Pathology
<p><b>Bone Marrow Aspirate:</b> 2 mL in EDTA tube.<br>
<b>Peripheral Blood:</b> 5 mL in EDTA tube.<br>
<b>H&E slide:</b> Required, plus paraffin block.<br>
<b>Cut Slides:</b> H&E slide (required) plus 10-14 unstained slides cut at 5+ microns.<br>
<b>Note on FFPE:</b> Paraffin block is preferred. Do not use zinc fixatives. If submitting slides, please use positively-charged slides and 10% NBF fixative. Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.<br>
<b>Do not use:</b> Mercury fixatives (B5). Highly acidic or prolonged decalcification processes will not yield sufficient nucleic acid to accurately perform molecular studies.<br>
<b>Note:</b> Test is TNA-based. Please select Extract & Hold - TNA if specimen hold service is desired.</p>
<b>Peripheral Blood:</b> 5 mL in EDTA tube.<br>
<b>H&E slide:</b> Required, plus paraffin block.<br>
<b>Cut Slides:</b> H&E slide (required) plus 10-14 unstained slides cut at 5+ microns.<br>
<b>Note on FFPE:</b> Paraffin block is preferred. Do not use zinc fixatives. If submitting slides, please use positively-charged slides and 10% NBF fixative. Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.<br>
<b>Do not use:</b> Mercury fixatives (B5). Highly acidic or prolonged decalcification processes will not yield sufficient nucleic acid to accurately perform molecular studies.<br>
<b>Note:</b> Test is TNA-based. Please select Extract & Hold - TNA if specimen hold service is desired.</p>
Flag Active
True
Orderable Test Description
<p>This panel is designed to detect key genetic alterations associated with angioimmunoblastic T-cell lymphoma (AITL) and peripheral T-cell lymphoma (PTCL) through next-generation sequencing (NGS) of all exons in the following genes: <br><br>
DNA NGS (SNV/Indel):<br>
IDH1, IDH2, DNMT3A, TET2, RHOA</p>
DNA NGS (SNV/Indel):<br>
IDH1, IDH2, DNMT3A, TET2, RHOA</p>
Orderable Turn Around Time
14 Days
NY Approved
False
Orderable Biomarkers JSON
{"DNA Sequencing": {"SNVs + Indels": ["DNMT3A", "IDH1", "IDH2", "TET2", "RHOA"]}}
Keywords string
precision profile, solid tumors, neo type, NeoTYPE Precision Profile for Solid Tumors. NeoTYPE® AITL/Peripheral T-Cell Lymphoma Profile
Title URL
neotype-aitl-peripheral-t-cell-lymphoma-profile
Clinical Significance
Angioimmunoblastic T-cell lymphoma (AITL) is a subtype of peripheral T-cell lymphoma (PTCL) and accounts for 20-25% of PTCLs. Peripheral T-cell lymphoma is known as an aggressive group of lymphoid malignancies and represent about 10-15% of non-Hodgkin lymphomas. Frequent mutations have been detected in the genes IDH1/2, DNMT3A, TET2 and RHOA in patients diagnosed with AITL. These mutations may play a role in the pathogenesis of AITL/PTCLs.
Storage and transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. Ship same day as drawn whenever possible. Please select Extract & Hold - TNA if specimen hold service is desired.