Code
MOG-NOTX-01CZ
Test
Active-Compendium
81407
Clinical
Oncology,Pathology
<p><b>Bone Marrow Aspirate:</b> 2 mL in EDTA tube.<br>
<b>Peripheral Blood:</b> 5 mL in EDTA tube.<br>
<b>Note:</b> Test is DNA-based. Please select Extract & Hold - DNA if specimen hold service is desired.</p>
<b>Peripheral Blood:</b> 5 mL in EDTA tube.<br>
<b>Note:</b> Test is DNA-based. Please select Extract & Hold - DNA if specimen hold service is desired.</p>
Flag Active
True
Orderable Test Description
This test uses bi-directional sequencing on exons 26, 27, and 34 of NOTCH1 for detection of sequence variant mutations. Testing can be performed on plasma when adequate leukemic cells are not available.
Orderable Turn Around Time
10 Days
Orderable Biomarkers
NY Approved
False
Orderable Biomarkers JSON
{"DNA Sequencing": {"SNVs + Indels": ["NOTCH1"]}}
Keywords string
notch1, notch1 mutation analysis , notch 1, notch 1 mutation, NOTCH1 Mutation Analysis
Title URL
notch1-mutation-analysis
Clinical Significance
NOTCH1 mutations are common in T-ALL, CLL, and mantle cell lymphoma. Mutations in ALL are associated with good prognosis, while mutations in CLL and mantle cell lymphoma are associated with poor prognosis.
Storage and transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. For fresh samples: refrigerate before shipping and ship same day as drawn whenever possible. Do not freeze. Please select extract & hold - DNA if specimen hold service is desired.