Code
MOG-CSFX-01BZ
Test
Active-Compendium
81479
Clinical
Oncology,Pathology
<p><b>Bone Marrow Aspirate:</b> 2 mL in EDTA tube.<br>
<b>Peripheral Blood:</b> 5 mL in EDTA tube.<br>
<b>Note:</b> Test is DNA-based. Please select Extract & Hold - DNA if specimen hold service is desired.</p>
<b>Peripheral Blood:</b> 5 mL in EDTA tube.<br>
<b>Note:</b> Test is DNA-based. Please select Extract & Hold - DNA if specimen hold service is desired.</p>
Flag Active
True
Orderable Test Description
This test uses bi-directional sequencing of exons 14 and 17 of the CSF3R gene, including the T618I mutation (T595I).
Orderable Turn Around Time
10 Days
Orderable Biomarkers
NY Approved
False
Orderable Biomarkers JSON
{"DNA Sequencing": {"SNVs + Indels": ["CSF3R"]}}
Keywords string
CSF3R , Mutation , Analysis CSF3R Mutation Analysis
Title URL
csf3r-mutation-analysis
Clinical Significance
The Colony Stimulating Factor 3 Receptor (CSF3R) gene is mutated in 59% of chronic neutrophilic leukemia (CNL) or atypical chronic myeloid leukemia (aCML). CSF3R mutation has been reported in 30-80% of leukemia arising in patients with severe congenital neutropenia. It has also been reported in 4% of colon cancer and 3% of small cell/squamous cell lung cancer. The presence of CSF3R mutation is important for diagnosis, classification, and prognosis of chronic myeloproliferative neoplasms.
Storage and transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. For fresh samples: refrigerate before shipping and ship same day as drawn whenever possible. Do not freeze. Please select extract & hold - DNA if specimen hold service is desired.