Code
FSH-AMLN-03BX
Panel
Active-Compendium
88374x8 automated. Codes may differ if manual analysis is performed.
Clinical
Pathology
<p><b>Bone Marrow Aspirate:</b> 1-2 mL in sodium heparin tube. EDTA tube is acceptable.<br>
<b>Peripheral Blood:</b> 2-5 mL in sodium heparin tube. EDTA tube is acceptable.<br>
<b>Fresh, Unfixed Tissue:</b> Tissue in RPMI.<br>
<b>Bone Marrow/Peripheral Blood Smear or Fresh Tissue Touch Preparation Slides:</b> Minimum 8 slides, labeled with specimen type.<br>
<b>Fluids:</b> Mix in equal parts with RPMI (specimen volume to RPMI ratio of 1:1).<br>
<b>Fixed Cell Suspension:</b> A client-prepared fixed cell suspension is acceptable if received in 3:1 Methanol:Glacial Acetic Acid.</p>
<b>Peripheral Blood:</b> 2-5 mL in sodium heparin tube. EDTA tube is acceptable.<br>
<b>Fresh, Unfixed Tissue:</b> Tissue in RPMI.<br>
<b>Bone Marrow/Peripheral Blood Smear or Fresh Tissue Touch Preparation Slides:</b> Minimum 8 slides, labeled with specimen type.<br>
<b>Fluids:</b> Mix in equal parts with RPMI (specimen volume to RPMI ratio of 1:1).<br>
<b>Fixed Cell Suspension:</b> A client-prepared fixed cell suspension is acceptable if received in 3:1 Methanol:Glacial Acetic Acid.</p>
Flag Active
True
Orderable Test Description
<p>This FISH Panel is designed to detect common cytogenetic abnormalities associated with acute myeloid leukemia (AML), which can provide valuable prognostic information. This panel includes the following probes:<br><br>
RPN1, MECOM (3q21, 3q26.2)<br>
5q-, -5 (5p15, 5q31, 5q33)<br>
7q-, -7 (Cen 7, 7q22, 7q31)<br>
Trisomy 8 (Cen 8)<br>
DEK/NUP214 (CAN) t(6;9)<br>
MLL (11q23)<br>
ETV6 (12p13)<br>
17p- (TP53 17p13.1, NF1 17q11.2)<br><br>
Test Customization: Probes may be ordered separately.</p>
RPN1, MECOM (3q21, 3q26.2)<br>
5q-, -5 (5p15, 5q31, 5q33)<br>
7q-, -7 (Cen 7, 7q22, 7q31)<br>
Trisomy 8 (Cen 8)<br>
DEK/NUP214 (CAN) t(6;9)<br>
MLL (11q23)<br>
ETV6 (12p13)<br>
17p- (TP53 17p13.1, NF1 17q11.2)<br><br>
Test Customization: Probes may be ordered separately.</p>
Orderable Turn Around Time
3-5 Days
Keywords
NY Approved
True
Orderable Biomarkers JSON
{"Fluorescence In Situ Hybridization (FISH)": {"Structural Rearrangement(s)": ["MECOM", "KMT2A", "NUP214"], "Deletion(s)": ["5q-", "TP53", "ETV6", "7q-"], "Trisomy": ["Chromosome 8"]}}
Keywords string
aml, aml non, aml non favorable, aml panel, AML Non-Favorable Risk Panel, non favorable, t(6;9), T(6;9) AML Non-Favorable Risk Panel
Title URL
aml-non-favorable-risk-panel
Clinical Significance
The AML Non-Favorable Risk FISH Panel accommodates US and international cytogenetic risk classifications for intermediate and adverse risk groups. This Panel was formerly called AML Extended Panel.
Storage and transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. For fresh samples: refrigerate before shipping and ship same day as drawn whenever possible. Do not freeze. NYS clients please provide date and time of collection.