Code
APT-ALKX-01AX
Test
Active-Compendium
88342 x 1 or 88341 x 1
Clinical
Pathology
<p><b>Cut Slides:</b> H&E slide (required) plus 2-3 unstained slides cut at 4-5 microns for each IHC test ordered.<br>
<b>Note on FFPE:</b> Paraffin block is preferred. Do not use zinc fixatives. If submitting slides, please use positively-charged slides and 10% NBF fixative. Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
<b>Note on FFPE:</b> Paraffin block is preferred. Do not use zinc fixatives. If submitting slides, please use positively-charged slides and 10% NBF fixative. Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Flag Active
True
Orderable Test Description
This test uses immunohistochemistry (IHC) to stain for ALK1 (ALK1 cline). ALK1 identifies normal human ALK protein expression and the NPM-ALK chimeric protein and is a useful tool for the identification of a subgroup of anaplastic large-cell lymphoma (ALCL) that are ALK positive.
Orderable Turn Around Time
24 Hours
Orderable Biomarkers
NY Approved
True
Orderable Biomarkers JSON
{"Immunohistochemistry (IHC)": {"Expression": ["ALK1"]}}
Keywords string
alk-1, alk1 ALK-1, (For heme cases)
Title URL
alk-1-for-heme-cases
Clinical Significance
ALK-1 is a membrane spanning tyrosine kinase receptor and member of insulin receptor family. ALK-1 overexpression occurs as a result of translocations, mutations and amplifications. Tumors with ALK-1 translocations are sensitive to ALK-1 inhibitors.
Storage and transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. Slides can be packed at room temperature. NYS clients please provide date and time of collection.