Code
NTG-TYPX-02CX
Profile
Active-Compendium
81457x1, 88377x2, 88360x1, 88342x1; add 81479x1 if reflexed to NTRK NGS Fusion Panel (default) or 88374x3 automated (88377x3 manual) if reflexed to NTRK 1-3 FISH Panel
81479
Clinical
Oncology,Pathology
FFPE tissue: Paraffin block preferred. Please use 10% buffered formalin fixative. Do not use zinc fixatives.
Flag Active
True
Orderable Test Description
<p>The NeoTYPE Thyroid Tumor Profile analyzes 32 biomarkers through a combination of next-generation sequencing (NGS), FISH, and IHC as listed below. Test orders include summary interpretation of all results to help guide treatment decisions. If Pan-TRK IHC is expressed or equivocal, reflex to either NTRK NGS Fusion Panel (Default) or NTRK 1-3 FISH Panel will be added. A microsatellite instability (MSI) NGS result of "indeterminate" will create a reflex to MSI by PCR as long as the tumor percentage is ≥40% and paired normal tissue is available. NGS (26 genes + 2 biomarkers): AKT1, ALK, ARID1A, ATM, BRAF, CDKN2A, CTNNB1, ERBB2, ERBB4, HRAS, KRAS, MEN1, MET, Microsatellite Instability (MSI), NF1, NF2, NRAS, PIK3CA, PTEN, RET, SMAD4, SMO, SRC, TERT Promoter, TP53, TSC1, TSC2, Tumor Mutation Burden (TMB) FISH (2 FISH): MET, RET (tech-only available) IHC (2 biomarkers): PD-L1 LDT, Pan-TRK (tech-only available for PD-L1).</p>
Orderable Turn Around Time
14 Days
Orderable Biomarkers
NY Approved
True
Orderable Biomarkers JSON
{"DNA Sequencing": {"SNVs + Indels": ["HRAS", "KRAS", "NRAS", "ALK", "MEN1", "NF1", "NF2", "RET", "CDKN2A", "TERT", "AKT1", "ARID1A", "ATM", "CTNNB1", "ERBB2", "ERBB4", "TP53", "MET", "TSC2", "TSC1", "PIK3CA", "PTEN", "SMAD4", "SMO", "SRC", "BRAF"], "CNVs": ["MET", "RET"], "Genomic Signatures": ["MSI", "TMB"]}, "Immunohistochemistry (IHC)": {"Expression": ["PD-L1", "NTRK1", "NTRK2", "NTRK3"]}}
Keywords string
precision profile, solid tumors, neo type, NeoTYPE Precision Profile for Solid Tumors. NeoTYPE® Thyroid Profile
Title URL
neotype-thyroid-profile
TAT Details
NGS: 14 Days
FISH: 7 Days
IHC: Global: 2 Days
Tech-Only (stain
only): 24 Hours
Potential Reflex Testing (Additional Time):
MSI by PCR: 5 Days
NTRK 1-3 FISH: 5 Days
NTRK NGS: 1-3 Days
Storage and transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.