Code
NTG-TYPX-02CX
Profile
Active-Compendium
81457x1, 88377x2, 88360x1, 88342x1; add 81479x1 if reflexed to NTRK NGS Fusion Panel (default) or 88374x3 automated (88377x3 manual) if reflexed to NTRK 1-3 FISH Panel
81479
Clinical
Oncology,Pathology
FFPE tissue: Paraffin block preferred. Please use 10% buffered formalin fixative. Do not use zinc fixatives.
Flag Active
True
Orderable Test Description
<p>The NeoTYPE Thyroid Tumor Profile analyzes <b>32 biomarkers</b> through a combination of next-generation sequencing (NGS), FISH, and IHC as listed below. Test orders include summary interpretation of all results to help guide treatment decisions.<br><br>
<b>NGS (26 genes + MSI and TMB)</b><br>
A microsatellite instability (MSI) NGS result of "indeterminate" will create a reflex to MSI by PCR as long as the tumor percentage is ≥40% and paired normal tissue is available.<br><br>
<b>FISH (2 biomarkers)</b><br>
MET, RET (tech-only available) <br><br>
<b>IHC (2 biomarkers)</b><br>
*PD-L1 LDT (tech-only available)<br>
*Pan-TRK <br>
Reflex rule: If Pan-TRK IHC is expressed or equivocal, reflex to either NTRK NGS Fusion Panel (Default) or NTRK 1-3 FISH Panel will be added. </p>
<b>NGS (26 genes + MSI and TMB)</b><br>
A microsatellite instability (MSI) NGS result of "indeterminate" will create a reflex to MSI by PCR as long as the tumor percentage is ≥40% and paired normal tissue is available.<br><br>
<b>FISH (2 biomarkers)</b><br>
MET, RET (tech-only available) <br><br>
<b>IHC (2 biomarkers)</b><br>
*PD-L1 LDT (tech-only available)<br>
*Pan-TRK <br>
Reflex rule: If Pan-TRK IHC is expressed or equivocal, reflex to either NTRK NGS Fusion Panel (Default) or NTRK 1-3 FISH Panel will be added. </p>
Orderable Turn Around Time
14 Days
Orderable Biomarkers
NY Approved
True
Orderable Biomarkers JSON
{"DNA Sequencing": {"SNVs + Indels": ["AKT1", "ALK", "ARID1A", "ATM", "BRAF", "CDKN2A", "CTNNB1", "ERBB2", "ERBB4", "HRAS", "KRAS", "MEN1", "MET", "NF1", "NF2", "NRAS", "PIK3CA", "PTEN", "RET", "SMAD4", "SMO", "SRC", "TERT", "TP53", "TSC1", "TSC2"], "Genomic Signatures": ["MSI", "TMB"]}, "Immunohistochemistry (IHC)": {"Expression": ["NTRK1", "NTRK2", "NTRK3", "PD-L1"]}, "Fluorescence In Situ Hybridization (FISH)": {"Amplification(s)": ["MET"], "Rearrangement(s)": ["RET"]}}
Keywords string
precision profile, solid tumors, neo type, NeoTYPE Precision Profile for Solid Tumors. NeoTYPE® Thyroid Profile
Title URL
neotype-thyroid-profile
TAT Details
NGS: 14 Days
FISH: 7 Days
IHC: Global: 2 Days
Tech-Only (stain
only): 24 Hours
Potential Reflex Testing (Additional Time):
MSI by PCR: 5 Days
NTRK 1-3 FISH: 5 Days
NTRK NGS: 1-3 Days
Storage and transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.