Code
NTG-OSTX-02CX
Profile
Active-Compendium
81457x1, 81479x1, 88377x2, 88360x1, 88342x1; add 81479x1 if reflexed to NTRK NGS Fusion Panel (default) or 88374x3 automated (88377x3 manual) if reflexed to NTRK 1-3 FISH Panel
81479
Clinical
Oncology,Pathology
FFPE tissue: Paraffin block preferred. Please use 10% buffered formalin fixative. Do not use zinc fixatives.
Flag Active
True
Orderable Test Description
<p>The NeoTYPE Other Solid Tumor Profile analyzes 30 biomarkers through a combination of next-generation sequencing (NGS), FISH, and IHC as listed below. Test orders include summary interpretation of all results to help guide treatment decisions. If Pan-TRK IHC is expressed or equivocal, reflex to either NTRK NGS Fusion Panel (Default) or NTRK 1-3 FISH Panel will be added. A microsatellite instability (MSI) NGS result of "indeterminate" will create a reflex to MSI by PCR as long as the tumor percentage is ≥20% for colorectal specimens or ≥40% with paired normal tissue available for non-colorectal specimens. NGS (24 genes + 2 biomarkers): AKT1, BRAF, EGFR, FGFR1, FGFR2, FGFR3, GNAS, HRAS, IDH1, IDH2, KIT, KRAS, MET, Microsatellite Instability (MSI), NOTCH1, NRAS, PDGFRA, PIK3CA, PTEN, PTPN11, SMAD4, SMO, SRC, TERT Promoter, TP53, Tumor Mutation Burden (TMB) FISH (2 FISH): MET, PTEN (tech-only available) IHC (2 biomarkers): PD-L1 LDT, Pan-TRK (tech-only available for PD-L1).</p>
Orderable Turn Around Time
14 Days
Orderable Biomarkers
NY Approved
True
Orderable Biomarkers JSON
{"DNA Sequencing": {"SNVs + Indels": ["HRAS", "IDH1", "IDH2", "KIT", "KRAS", "NRAS", "NOTCH1", "PTPN11", "TERT", "AKT1", "FGFR2", "FGFR3", "EGFR", "TP53", "FGFR1", "MET", "PDGFRA", "PIK3CA", "GNAS", "PTEN", "SMAD4", "SMO", "SRC", "BRAF"], "Genomic Signatures": ["MSI", "TMB"]}, "Immunohistochemistry (IHC)": {"Expression": ["PD-L1", "NTRK1", "NTRK2", "NTRK3"]}}
Keywords string
Other Solid Tumor, neotype, solid, neo type, NeoTYPE Other Solid Tumor Profile. NeoTYPE® Other Solid Tumor Profile
Title URL
neotype-other-solid-tumor-profile
TAT Details
NGS: 14 Days
FISH: 7 Days
IHC: Global: 2 Days
Tech-Only (stain
only): 24 Hours
Potential Reflex Testing (Additional Time):
MSI by PCR: 5 Days
NTRK 1-3 FISH: 5 Days
NTRK NGS: 1-3 Days
Storage and transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.