NeoTYPE® Melanoma Profile | NeoGenomics Laboratories

Code

NTG-MAPX-02CX

Profile

Active-Compendium

81457x1, 88377x1, 88360x1, 88342x1; add 81479x1 if reflexed to NTRK NGS Fusion Panel (default) or 88374x3 automated (88377x3 manual) if reflexed to NTRK 1-3 FISH Panel

81479

Clinical

Oncology,Pathology

FFPE tissue: Paraffin block (preferred). Please use 10% buffered formalin fixative. Do not use zinc fixatives.

Solid Tumors

Melanoma/Skin

Mon, 01/13/2025 - 12:00

Wed, 01/28/2026 - 12:00

Next Generation Sequencing (NGS)

Global

Flag Active

True

Orderable Test Description

<p>The NeoTYPE Melanoma Tumor Profile analyzes 30 biomarkers through a combination of next-generation sequencing (NGS), FISH, and IHC as listed below. Test orders include summary interpretation of all results to help guide treatment decisions. If Pan-TRK IHC is expressed or equivocal, reflex to either NTRK NGS Fusion Panel (Default) or NTRK 1-3 FISH Panel will be added. A microsatellite instability (MSI) NGS result of "indeterminate" will create a reflex to MSI by PCR as long as the tumor percentage is ≥40% and paired normal tissue is available. NGS (24 genes + 2 biomarkers): AKT1, BAP1, BRAF, CDK4, CDKN2A, CTNNB1, EGFR, ERBB2, ERBB4, FGFR1, FGFR2, FGFR3, GNA11, GNAQ, HRAS, KIT, KRAS, Microsatellite Instability (MSI), NBN, NF1, NRAS, PDGFRA, SMO, SRC, TERT Promoter, Tumor Mutation Burden (TMB) FISH (1 FISH): PTEN (tech-only available) IHC (2 biomarkers): PD-L1 IHC, Pan-TRK (tech-only available for PD-L1).</p>

Orderable Turn Around Time

14 Days

Keywords

neo type

melanoma

melanoma profile

NeoTYPE Melanoma Profile

Meta Description

The NeoTYPE Melanoma Profile assesses the most commonly-mutated driver mutations in primary or metastatic melanoma to determine prognosis and identify established and clinical trial-based therapeutic options.

Orderable Biomarkers

NY Approved

True

Orderable Biomarkers JSON

{"DNA Sequencing": {"SNVs + Indels": ["HRAS", "KIT", "KRAS", "NRAS", "NF1", "CDK4", "CDKN2A", "TERT", "AKT1", "FGFR2", "FGFR3", "CTNNB1", "EGFR", "ERBB2", "ERBB4", "FGFR1", "GNA11", "PDGFRA", "NBN", "GNAQ", "SMO", "SRC", "BAP1", "BRAF"], "Genomic Signatures": ["MSI", "TMB"], "CNVs": ["PTEN"]}, "Immunohistochemistry (IHC)": {"Expression": ["PD-L1", "NTRK1", "NTRK3", "NTRK2"]}}

Keywords string

neo type, melanoma, melanoma profile, NeoTYPE Melanoma Profile NeoTYPE® Melanoma Profile

Title URL

neotype-melanoma-profile

TAT Details

NGS: 14 Days
FISH: 7 Days
Potential Reflex Testing (Additional Time):
MSI by PCR: 5 Days
NTRK 1-3 FISH: 5 Days
NTRK NGS: 1-3 Days

Storage and transportation

Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.