NeoTYPE® Liver/Biliary Tumor Profile | NeoGenomics Laboratories

Code

NTG-LBTX-02CX

Profile

Active-Compendium

81457x1, 88377x3, 88360x1, 88342x1; add 81479x1 if reflexed to NTRK NGS Fusion Panel (default) or 88374x3 automated (88377x3 manual) if reflexed to NTRK 1-3 FISH Panel

81479

Clinical

Oncology,Pathology

FFPE tissue: Paraffin block preferred. Please use 10% buffered formalin fixative. Do not use zinc fixatives.

Solid Tumors

Biliary tract

Liver

Mon, 01/13/2025 - 12:00

Wed, 01/28/2026 - 12:00

Next Generation Sequencing (NGS)

Global

Flag Active

True

Orderable Test Description

<p>The NeoTYPE Liver/Biliary Tumor Profile analyzes 38 biomarkers through a combination of next-generation sequencing (NGS), FISH, and IHC as listed below. Test orders include summary interpretation of all results to help guide treatment decisions. If Pan-TRK IHC is expressed or equivocal, reflex to either NTRK NGS Fusion Panel (Default) or NTRK 1-3 FISH Panel will be added. A microsatellite instability (MSI) NGS result of "indeterminate" will create a reflex to MSI by PCR as long as the tumor percentage is ≥40% and paired normal tissue is available. NGS (32 genes + 2 biomarkers): AKT1, APC, ARID1A, ATM, BAP1, BRAF, CDKN2A, CTNNB1, EGFR, ERBB2, ERBB4, FGFR1 (mutations), FGFR2 (mutations), FGFR3 (mutations), HRAS, IDH1, IDH2, KRAS, MET, Microsatellite Instability (MSI), NF1, NOTCH1, NRAS, PBRM1, PIK3CA, PTEN, SMAD4, SMO, SRC, TERT Promoter, TP53, TSC1, TSC2, Tumor Mutation Burden (TMB) FISH (3 FISH): FGFR2 rearrangement, MET, PTEN (tech-only available) IHC (2 biomarkers): PD-L1 LDT, Pan-TRK (tech-only available for PD-L1).</p>

Orderable Turn Around Time

14 Days

Keywords

NeoTYPE Liver/Biliary Tumor Profile. IDH

Meta Description

This test is performed by sequencing the entire coding regions of the genes listed unless another method is noted. AKT1, ATM, BRAF, CDKN2A, CTNNB1, EGFR, ERBB2, ERBB4, FGFR1 (mutations), FGFR2 (mutations), FGFR3 (mutations), HRAS, IDH1, IDH2, KRAS, MET, NOTCH1, NRAS, PIK3CA, PTEN, SMAD4, SMO, SRC, TP53, MET FISH, PTEN FISH and PD-L1 IHC. Tumor Mutation Burden (TMB) testing and individual genes from a validated list of genes can be added. Test orders include summary interpretation of all results together. FISH components of NeoTYPE Profiles may be ordered as "Tech-Only" by pathology clients who wish to perform the professional component.

Orderable Biomarkers

NY Approved

True

Orderable Biomarkers JSON

{"DNA Sequencing": {"CNVs": ["FGFR2", "MET", "PTEN"], "SNVs + Indels": ["HRAS", "IDH1", "IDH2", "KRAS", "NRAS", "NOTCH1", "NF1", "CDKN2A", "TERT", "AKT1", "ARID1A", "ATM", "FGFR2", "FGFR3", "CTNNB1", "EGFR", "ERBB2", "ERBB4", "SMAD4", "TP53", "FGFR1", "MET", "TSC2", "TSC1", "PIK3CA", "PTEN", "APC", "SMO", "SRC", "BAP1", "BRAF", "PBRM1"], "Genomic Signatures": ["MSI", "TMB"]}, "Immunohistochemistry (IHC)": {"Expression": ["PD-L1", "NTRK1", "NTRK3", "NTRK2"]}}

Keywords string

NeoTYPE, Liver/Biliary, liver cancer, biliary cancer, cholangiocarcinoma, NeoTYPE Liver/Biliary Tumor Profile. IDH NeoTYPE® Liver/Biliary Tumor Profile

Title URL

neotype-liver-biliary-tumor-profile

TAT Details

NGS: 14 Days
FISH: 7 Days
IHC: Global: 2 Days
Tech-Only (stain
only): 24 Hours
Potential Reflex Testing (Additional Time):
MSI by PCR: 5 Days
NTRK 1-3 FISH: 5 Days
NTRK NGS: 1-3 Days

Storage and transportation

Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.