Code
NTG-HNTX-02CX
Profile
Active-Compendium
81457x1, 88377x3, 88360x1, 88342x1, 88365x1; add 81194x1 if reflexed to NTRK NGS Fusion Panel (default) or 88374x3 automated (88377x3 manual) if reflexed to NTRK 1-3 FISH Panel
81479x1, 88377x3, 88360x1, 88342x1, 88365x1; add 81194x1 if reflexed to NTRK NGS Fusion Panel (default) or 88374x3 automated (88377x3 manual) if reflexed to NTRK 1-3 FISH Panel
Clinical
Oncology,Pathology
FFPE tissue: Paraffin block preferred. Please use 10% buffered formalin fixative. Do not use zinc fixatives.
Flag Active
True
Orderable Test Description
<p>The NeoTYPE Head & Neck Tumor Profile analyzes 34 biomarkers through a combination of next-generation sequencing (NGS), other molecular methods, FISH, and IHC as listed below. Test orders include summary interpretation of all results that help guide treatment decisions. If Pan-TRK IHC is expressed or equivocal, reflex to either NTRK NGS Fusion Panel (Default) or NTRK 1-3 FISH Panel will be added. A microsatellite instability (MSI) NGS result of "indeterminate" will create a reflex to MSI by PCR as long as the tumor percentage is ≥40% and paired normal tissue is available. NGS (27 genes + 2 biomarkers): AKT1, ATM, BRAF, CDKN2A, CTNNB1, EGFR, ERBB2, ERBB4, FBXW7, FGFR1, FGFR2, FGFR3, HRAS, IDH1, IDH2, KRAS, MET, Microsatellite Instability (MSI), NFE2L2, NOTCH1, NRAS, PIK3CA, PTEN, RB1, SMO, SRC, TERT Promoter, TP53, Tumor Mutation Burden (TMB) Other Methodology (1 biomarker): HPV RNA ISH 16/18 (High Risk) FISH (3 FISH): MET, PTEN, RET (tech-only available) IHC (2 biomarkers): PD-L1 22C3, Pan-TRK (tech-only available for PD-L1).</p>
Orderable Turn Around Time
14 Days
Orderable Biomarkers
NY Approved
True
Orderable Biomarkers JSON
{"DNA Sequencing": {"SNVs + Indels": ["HRAS", "IDH1", "IDH2", "KRAS", "NRAS", "NOTCH1", "FBXW7", "NFE2L2", "RB1", "CDKN2A", "TERT", "AKT1", "ATM", "FGFR2", "FGFR3", "CTNNB1", "EGFR", "ERBB2", "ERBB4", "TP53", "FGFR1", "MET", "PIK3CA", "PTEN", "SMO", "SRC", "BRAF"], "CNVs": ["MET", "RET", "PTEN"], "Genomic Signatures": ["MSI", "TMB"]}, "Immunohistochemistry (IHC)": {"Expression": ["PD-L1", "NTRK1", "NTRK2", "NTRK3"]}, "In Situ Hybridization (ISH)": {"Pathogen Detection": ["HPV 16/18"]}}
Keywords string
precision profile, solid tumors, neo type, NeoTYPE Precision Profile for Solid Tumors. NeoTYPE® Head & Neck Tumor Profile
Title URL
neotype-head-neck-tumor-profile
TAT Details
NGS: 14 Days
FISH: 7 Days
IHC: Global: 2 Days
Tech-Only (stain
only): 24 Hours
Potential Reflex Testing (Additional Time):
MSI by PCR: 5 Days
NTRK 1-3 FISH: 5 Days
NTRK NGS: 1-3 Days
Storage and transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.