Code
NTG-GTPX-02CX
Profile
Active-Compendium
81457x1, 88377x2, 88360x1, 88342x1; add 88361x4 if MMR IHC is selected; add 81479x1 if reflexed to NTRK NGS Fusion Panel (default) or 88374x3 automated (88377x3 manual) if reflexed to NTRK 1-3 FISH Panel
81479
Clinical
Oncology,Pathology
FFPE tissue: Paraffin block preferred. Please use 10% buffered formalin fixative. Do not use zinc fixatives.
Flag Active
True
Orderable Test Description
<p>The NeoTYPE® Gastric Tumor Profile analyzes 39 biomarkers through a combination of next-generation sequencing (NGS), FISH, and IHC as listed below. Test orders include summary interpretation of all results to help guide treatment decisions. If Pan-TRK IHC is expressed or equivocal, reflex to either NTRK NGS Fusion Panel (Default) or NTRK 1-3 FISH Panel will be added. A microsatellite instability (MSI) NGS result of "indeterminate" will create a reflex to MSI by PCR as long as the tumor percentage is ≥40% and paired normal tissue is available. NGS (33 genes + 2 biomarkers): AKT1, ARID1A, BRAF, CDH1, CDKN2A, EGFR, ERBB2, ERBB3, ERBB4, FGFR1, FGFR2, FGFR3, HRAS, KIT, KRAS, MET, Microsatellite Instability (MSI), MLH1, MSH2, MSH6, NOTCH1, NRAS, PDGFRA, PIK3CA, PMS2, PREX2, PTEN, RNF43, SMAD4, SMO, SRC, TGFBR2, TERT Promoter, TP53, Tumor Mutation Burden (TMB) FISH (2 FISH): MET, PTEN (tech-only available) IHC (6 biomarkers): MMR (opt-out available), PD-L1 22C3, Pan-TRK (tech-only available for MMR and PD-L1).</p>
Orderable Turn Around Time
14 Days
Orderable Biomarkers
NY Approved
True
Orderable Biomarkers JSON
{"DNA Sequencing": {"SNVs + Indels": ["HRAS", "KIT", "KRAS", "NRAS", "NOTCH1", "RNF43", "PREX2", "CDKN2A", "TERT", "AKT1", "ERBB3", "ARID1A", "FGFR2", "FGFR3", "CDH1", "EGFR", "ERBB2", "ERBB4", "TGFBR2", "FGFR1", "MET", "SMO", "MLH1", "MSH2", "MSH6", "PDGFRA", "PIK3CA", "PMS2", "PTEN", "SMAD4", "TP53", "SRC", "BRAF"], "CNVs": ["MET", "PTEN"], "Genomic Signatures": ["MSI", "TMB"]}, "Immunohistochemistry (IHC)": {"Expression": ["PD-L1", "NTRK1", "NTRK2", "NTRK3"]}}
Keywords string
precision profile, solid tumors, neo type, NeoTYPE Precision Profile for Solid Tumors. NeoTYPE® Gastric Tumor Profile
Title URL
neotype-gastric-tumor-profile
TAT Details
NGS: 14 Days
FISH: 7 Days
IHC: Global: 2 Days
Tech-Only (stain
only): 24 Hours
Potential Reflex Testing (Additional Time):
MSI by PCR: 5 Days
NTRK 1-3 FISH: 5 Days
NTRK NGS: 1-3 Days
Storage and transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.