Code
NTG-CCPX-02CX
Profile
Active-Compendium
81457x1, 88360x1, 88374x1 or 88377x1
Clinical
Oncology,Pathology
FFPE tissue: Paraffin block preferred. Please use 10% buffered formalin fixative. Do not use zinc fixatives.
Flag Active
True
Orderable Test Description
<p>The NeoTYPE Cholangiocarcinoma Profile analyzes 19 biomarkers through a combination of next-generation sequencing (NGS), FISH, and IHC as listed below. Test orders include summary interpretation of all results to help guide treatment decisions. A microsatellite instability (MSI) NGS result of "indeterminate" will create a reflex to MSI by PCR as long as the tumor percentage is ≥40% and paired normal tissue is available. NGS (15 genes + 2 biomarkers): APC, ARID1A, BAP1, BRAF, EGFR, ERBB2, HRAS, IDH1, IDH2, KRAS, MET (c-MET), NRAS, PBRM1, SMAD4, TP53, plus Microsatellite instability (MSI) and Tumor Mutation Burden (TMB). FISH (1 biomarker): FGFR2 IHC (1 biomarker): PD-L1 LDT.</p>
Orderable Turn Around Time
14 Days
Orderable Biomarkers
NY Approved
True
Orderable Biomarkers JSON
{"DNA Sequencing": {"SNVs + Indels": ["HRAS", "IDH1", "IDH2", "KRAS", "NRAS", "ARID1A", "EGFR", "ERBB2", "MET", "BRAF", "SMAD4", "TP53", "APC", "BAP1", "PBRM1"], "Genomic Signatures": ["MSI", "TMB"], "CNVs": ["FGFR2"]}, "Immunohistochemistry (IHC)": {"Expression": ["PD-L1"]}}
Keywords string
chollangio, cholangiocarcinoma, cholangio cancer, gene fusion NeoTYPE® Cholangiocarcinoma Profile
Title URL
neotype-cholangiocarcinoma-profile
TAT Details
NGS: 14 Days
FISH: 5 Days
IHC: Global: 2 Days
Tech-Only (stain
only): 24 Hours
Potential Reflex Testing (Additional Time):
MSI by PCR: 5 Days
Storage and transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.