Code
NTG-ALNX-02CX
Profile
Active-Compendium
81450x1, 88374x2
Clinical
Oncology,Pathology
<p><b>Bone Marrow Aspirate:</b> 2-3 mL in EDTA tube.<br> <b>Peripheral Blood:</b> 3-5 mL in EDTA tube.<br> <b>H&E slide:</b> H&E slide (required) plus paraffin block.<br> <b>Cut Slides:</b> H&E slide (required) plus 5-10 unstained slides cut at 5+ microns.<br> <b>Note on FFPE:</b> Paraffin block is preferred. Do not use zinc fixatives. If submitting slides, please use positively-charged slides and 10% NBF fixative. Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.<br> <b>Do not use mercury fixatives (B5):</b> Highly acidic or prolonged decalcification processes will not yield sufficient nucleic acid to accurately perform molecular studies.<br> <b>Note:</b> Test is TNA-based. Please select Extract & Hold - TNA If specimen hold service is desired.<br> <b>Note for FFPE:</b> Not validated specimen type for FISH testing.</p>
Flag Active
True
Orderable Test Description
<p>The NeoTYPE ALL Profile analyzes 50 genes to detect DNA and RNA alterations through a combination of next-generation sequencing (NGS) and FISH as noted below. Test reports include a summary interpretation of all results together. FISH components may be ordered as "Tech-Only" by pathology clients who wish to perform the professional component.<br><br>
DNA Sequencing: SNVs/InDels (29 Genes):<br>
ABL1, ABL2, CDKN2A, CRLF2, CSF1R, EPOR, FBXW7, FGFR2, FGFR3, FLT3, IDH1, IDH2, IKZF1, IL7R, JAK1, JAK2, JAK3, KRAS, NOTCH1, NRAS, NTRK1, NTRK2, NTRK3, PAX5, PDGFRA, PDGFRB, PHF6, SH2B3, and TP53<br><br>
Copy Number Variations (3 Genes):<br>
CDKN2A, IKZF1, and TP53 Note: Only copy number loss is reported as it is a clinically relevant abnormality for these tumor suppressor genes.<br><br>
RNA Sequencing: Fusions (34 Genes):<br>
ABL1, ABL2, BCL11B, BCR, CRLF2, CSF1R, EPOR, ETV6, FGFR1, FLT3, IKZF1, JAK2, KMT2A, MEF2D, MLLT10, MYB, NTRK1, NTRK2, NTRK3, NUP214, NUP98, PAX5, PBX1, PDGFRA, PDGFRB, PTK2B, RUNX1, STIL, TAL1, TCF3, TLX1, TLX3, TYK2, and ZNF384<br><br>
FISH (2 Genes):<br>
CRLF2 (Xp22.33/Yp11.32)<br>
EPOR (19p13.2)</p>
DNA Sequencing: SNVs/InDels (29 Genes):<br>
ABL1, ABL2, CDKN2A, CRLF2, CSF1R, EPOR, FBXW7, FGFR2, FGFR3, FLT3, IDH1, IDH2, IKZF1, IL7R, JAK1, JAK2, JAK3, KRAS, NOTCH1, NRAS, NTRK1, NTRK2, NTRK3, PAX5, PDGFRA, PDGFRB, PHF6, SH2B3, and TP53<br><br>
Copy Number Variations (3 Genes):<br>
CDKN2A, IKZF1, and TP53 Note: Only copy number loss is reported as it is a clinically relevant abnormality for these tumor suppressor genes.<br><br>
RNA Sequencing: Fusions (34 Genes):<br>
ABL1, ABL2, BCL11B, BCR, CRLF2, CSF1R, EPOR, ETV6, FGFR1, FLT3, IKZF1, JAK2, KMT2A, MEF2D, MLLT10, MYB, NTRK1, NTRK2, NTRK3, NUP214, NUP98, PAX5, PBX1, PDGFRA, PDGFRB, PTK2B, RUNX1, STIL, TAL1, TCF3, TLX1, TLX3, TYK2, and ZNF384<br><br>
FISH (2 Genes):<br>
CRLF2 (Xp22.33/Yp11.32)<br>
EPOR (19p13.2)</p>
Orderable Turn Around Time
14 Days
Orderable Biomarkers
NY Approved
True
Orderable Biomarkers JSON
{"DNA Sequencing": {"SNVs + Indels": ["IDH1", "IDH2", "KRAS", "NOTCH1", "PHF6", "NRAS", "FBXW7", "PAX5", "ABL1", "ABL2", "CDKN2A", "CRLF2", "CSF1R", "TP53", "EPOR", "FGFR2", "FGFR3", "FLT3", "IKZF1", "IL7R", "JAK1", "JAK2", "JAK3", "NTRK1", "NTRK3", "NTRK2", "PDGFRA", "SH2B3", "PDGFRB"], "CNVs": ["CDKN2A", "IKZF1", "BCORL1", "TP53"]}, "RNA Sequencing": {"Fusions": ["MYB", "BCL11B", "ABL1", "ABL2", "BCR", "CRLF2", "CSF1R", "EPOR", "ETV6", "FGFR1", "FLT3", "IKZF1", "JAK2", "STIL", "MEF2D", "MLLT10", "KMT2A", "NTRK2", "NTRK1", "NTRK3", "NUP98", "PAX5", "PBX1", "PDGFRB", "PDGFRA", "PTK2B", "RUNX1", "TAL1", "TCF3", "NUP214", "TLX3", "TYK2", "ZNF384", "TLX1"]}, "Fluorescence In Situ Hybridization (FISH)": {"CNVs": ["CRLF2", "EPOR"]}}
Keywords string
Acute lymphoblastic leukemia Myeloid disorders heme cancers hematologic malignancies NeoTYPE® ALL Profile for New York
Title URL
neotype-all-profile-for-new-york
TAT Details
NGS: 14 Days
FISH: 5 Days
Storage and transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. For fresh samples: refrigerate before shipping and ship same day as drawn whenever possible. Do not freeze. NYS clients please provide date and time of collection. Please select Extract & Hold - TNA if specimen hold service is desired.