Code
MOG-TRGX-01BZ
Test
Active-Compendium
81342
Clinical
Oncology,Pathology
<p><b>Bone Marrow Aspirate:</b> 2 mL in EDTA tube.<br> <b>Peripheral Blood:</b> 5 mL in EDTA tube.<br> <b>H&E slide:</b> H&E slide (required) plus paraffin block.<br> <b>Cut Slides:</b> H&E slide (required) plus 4-5 unstained slides cut at 5+ microns.<br> <b>Fresh, Unfixed Tissue:</b> Two pieces minimum, 0.2 cm3 in RPMI.<br> <b>Note on FFPE:</b> Paraffin block is preferred. Do not use zinc fixatives. If submitting slides, please use positively-charged slides and 10% NBF fixative. Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.<br> <b>Note:</b> Test is DNA-based. Please select Extract & Hold - DNA If specimen hold service is desired.<br> <b>Note on Fresh Tissue:</b> Not suitable for freeze & hold option.</p>
Flag Active
True
Orderable Test Description
<p>This test uses PCR on variable and joining regions to detect clonal T-cell receptor (TCR) gamma gene rearrangements. <br><br>
Test Customization: This test may be ordered concurrently with the T-Cell Receptor Beta Gene Rearrangement assay.</p>
Test Customization: This test may be ordered concurrently with the T-Cell Receptor Beta Gene Rearrangement assay.</p>
Orderable Turn Around Time
7 Days
Keywords
Orderable Biomarkers
NY Approved
True
Orderable Biomarkers JSON
{"Polymerase Chain Reaction (PCR)": {"Rearrangement(s)": ["TCR gamma"]}}
Keywords string
T-Cell , gene rearrangement, T-Cell Gene Rearrangement, clonal T-cell receptor, monoclonal T-cell receptor, lymphoproliferative disorders, T-Cell Receptor Gamma Gene Rearrangement. TCR, TCRG T-Cell Receptor Gamma Gene Rearrangement
Title URL
t-cell-receptor-gamma-gene-rearrangement
Clinical Significance
T-cell receptor (TCR) gene rearrangement analysis is commonly used for determining clonality in the diagnostic evaluation of T-cell lymphomas and leukemias. TCR beta gene (tested separately) and gamma gene rearrangement analysis (as provided in this test) together will detect most clonal TCR rearrangements in patients with T-cell lymphomas/leukemias. Results should be interpreted in clinical context for diagnosis of T-cell lymphoproliferative disorders.
Storage and transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. For fresh samples: refrigerate before shipping and ship same day as drawn whenever possible. Do not freeze. Please select extract & hold - DNA if specimen hold service is desired. NYS clients please provide date and time of collection.