Code
MOG-TRBX-01BZ
Test
Active-Compendium
81340
Clinical
Oncology,Pathology
<p><b>Bone Marrow Aspirate:</b> 2 mL in EDTA tube.<br>
<b>Peripheral Blood:</b> 5 mL in EDTA tube.<br>
<b>H&E slide:</b> Required, plus paraffin block.<br>
<b>Cut Slides:</b> H&E slide (required) plus 4-5 unstained slides cut at 5+ microns.<br>
<b>Fresh, Unfixed Tissue:</b> Two pieces minimum, 0.2 cm³ in RPMI.<br>
<b>Note on FFPE:</b> Paraffin block is preferred. Do not use zinc fixatives. If submitting slides, please use positively-charged slides and 10% NBF fixative. Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.<br>
<b>Note:</b> Test is DNA-based. Please select Extract & Hold - DNA if specimen hold service is desired.<br>
<b>Note on Fresh Tissue:</b> Not suitable for freeze & hold option.</p>
<b>Peripheral Blood:</b> 5 mL in EDTA tube.<br>
<b>H&E slide:</b> Required, plus paraffin block.<br>
<b>Cut Slides:</b> H&E slide (required) plus 4-5 unstained slides cut at 5+ microns.<br>
<b>Fresh, Unfixed Tissue:</b> Two pieces minimum, 0.2 cm³ in RPMI.<br>
<b>Note on FFPE:</b> Paraffin block is preferred. Do not use zinc fixatives. If submitting slides, please use positively-charged slides and 10% NBF fixative. Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.<br>
<b>Note:</b> Test is DNA-based. Please select Extract & Hold - DNA if specimen hold service is desired.<br>
<b>Note on Fresh Tissue:</b> Not suitable for freeze & hold option.</p>
Flag Active
True
Orderable Test Description
<p>This test uses PCR and fragment analysis to qualitatively detect monoclonal T-cell receptor (TCR) beta gene rearrangements according to BIOMED-2 consensus primer design. <br><br>Test Customization: This test may be ordered concurrently, or after a negative result, with the T-Cell Receptor Gamma Gene.<br><br>Rearrangement assay. This improves TCR rearrangement detection by ~10% in T-cell leukemias/lymphomas.</p>
Orderable Turn Around Time
7 Days
Orderable Biomarkers
NY Approved
True
Orderable Biomarkers JSON
{"Polymerase Chain Reaction (PCR)": {"Rearrangement(s)": ["TCR beta"]}}
Keywords string
This test provides qualitative detection of monoclonal T-cell receptor (TCR) beta gene rearrangements by PCR and fragment analysis according to BIOMED-2 consensus primer design. T-Cell Receptor Beta Gene Rearrangement
Title URL
t-cell-receptor-beta-gene-rearrangement
Clinical Significance
T-cell receptor (TCR) gene rearrangement analysis is commonly used for determining clonality in the diagnostic evaluation of T-cell lymphomas and leukemias. TCR gamma gene (tested separately) and beta gene rearrangement analysis (as provided in this test) together will detect most clonal TCR rearrangements in patients with T-cell lymphomas/leukemias. Results should be interpreted in clinical context for diagnosis of T-cell lymphoproliferative disorders.
Storage and transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. For fresh samples: refrigerate before shipping and ship same day as drawn whenever possible. Do not freeze. Please select extract & hold - DNA if specimen hold service is desired. NYS clients please provide date and time of collection.