Code
MOG-BGRX-01BZ
Test
Active-Compendium
81261, 81264
81479
Clinical
Pathology
<p><b>Bone Marrow Aspirate:</b> 2 mL in EDTA tube.<br>
<b>Peripheral Blood:</b> 5 mL in EDTA tube.<br>
<b>H&E slide (required) plus paraffin block.</b><br>
<b>Cut Slides:</b> H&E slide (required) plus 4-5 unstained slides cut at 5+ microns.<br>
<b>Fresh, Unfixed Tissue:</b> Two pieces minimum, 0.2 cm³ in RPMI.<br>
<b>Note on FFPE:</b> Paraffin block is preferred. Do not use zinc fixatives. If submitting slides, please use positively-charged slides and 10% NBF fixative. Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.<br>
<b>Note:</b> Test is DNA-based. Please select Extract & Hold - DNA if specimen hold service is desired.<br>
<b>Note on Fresh Tissue:</b> Not suitable for freeze & hold option.</p>
<b>Peripheral Blood:</b> 5 mL in EDTA tube.<br>
<b>H&E slide (required) plus paraffin block.</b><br>
<b>Cut Slides:</b> H&E slide (required) plus 4-5 unstained slides cut at 5+ microns.<br>
<b>Fresh, Unfixed Tissue:</b> Two pieces minimum, 0.2 cm³ in RPMI.<br>
<b>Note on FFPE:</b> Paraffin block is preferred. Do not use zinc fixatives. If submitting slides, please use positively-charged slides and 10% NBF fixative. Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.<br>
<b>Note:</b> Test is DNA-based. Please select Extract & Hold - DNA if specimen hold service is desired.<br>
<b>Note on Fresh Tissue:</b> Not suitable for freeze & hold option.</p>
Flag Active
True
Orderable Test Description
This test uses PCR to detect clonal IgH gene rearrangements in regions 1,2,3 and joining regions. IgK gene rearrangement analysis is performed using specific oligonucleotides recognizing the Vk, intragenic, and jK regions.
Orderable Turn Around Time
7 Days
Keywords
Orderable Biomarkers
NY Approved
True
Orderable Biomarkers JSON
{"Polymerase Chain Reaction (PCR)": {"Rearrangement(s)": ["IgH"]}}
Keywords string
b cell, b, Gene, Rearrangement B-Cell Gene Rearrangement
Title URL
b-cell-gene-rearrangement
Clinical Significance
B-Cell gene rearrangement testing is used for identifying clonal B cell populations, which are highly suggestive of B cell malignancies. This assay is useful in the diagnosis, staging or monitoring of various lymphomas and other B-cell lymphoproliferative diseases, however, not all clonal populations are malignant. Also, a negative result does not entirely exclude the presence of a clonal B-cell immunoglobulin gene rearrangement. Up to 20% of B-cell lymphoproliferative disorders can be negative by PCR evaluation. So, the results from this test must be interpreted within the context of clinical, morphologic and immunophenotypic findings.
Storage and transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. For fresh samples: refrigerate before shipping and ship same day as drawn whenever possible. Do not freeze. Please select extract & hold - DNA if specimen hold service is desired. NYS clients please provide date and time of collection.