TP63 Rearrangement

Code
FSH-TPSR-01BX
Panel
Active-Compendium
88377x2 manual or 88374x2 automated
Clinical
Pathology
Bone Marrow Aspirate: N/A
Peripheral Blood: N/A
Fresh, Unfixed Tissue: N/A
Fluids: N/A
Paraffin Block: H&E slide (required) plus paraffin block. Circle H&E for tech-only.
Cut Slides: H&E slide (required) plus 2 unstained slides cut at 4 microns. Circle H&E for tech-only.
Flag Active
True
Orderable Test Description
Probes: TP63 (3q28) | TBL1XR1/TP63 [inv(3)(q26q28)]
Disease(s): Anaplastic large cell lymphoma (ALCL), peripheral T-cell lymphoma (PTCL)
Note: Probes are not orderable separately; concurrent analysis is necessary due to proximity of breakpoints in the most common fusion rearrangement.
Orderable Turn Around Time
3-5 Days
Keywords
Meta Description
TP63 rearrangements define a subset of ALK-negative ALCL cases associated with aggressive course and poor outcome. This FISH test includes TBL1XR1/TP63 fusion analysis.
Orderable Biomarkers
NY Approved
True
Orderable Biomarkers JSON
{"Fluorescence In Situ Hybridization (FISH)": {"Structural Rearrangement(s)": ["TP63"]}}
Keywords string
p63, Np63, delta Np63, p63 TP63 Rearrangement
Title URL
tp63-rearrangement
Storage and transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.