Code
FSH-RABA-01BX
Test
Active-Compendium
88377x1 manual or 88374x1 automated.
Clinical
Pathology
<p><b>Bone Marrow Aspirate:</b> 1-2 mL in sodium heparin tube. EDTA tube is acceptable.<br>
<b>Peripheral Blood:</b> 2-5 mL in sodium heparin tube. EDTA tube is acceptable.<br>
<b>Fresh, Unfixed Tissue:</b> Tissue in RPMI.<br>
<b>Bone Marrow/Peripheral Blood Smear or Fresh Tissue Touch Preparation Slides:</b> Minimum 1 slide, labeled with specimen type.<br>
<b>Fluids:</b> Mix in equal parts with RPMI (specimen volume to RPMI ratio of 1:1).<br>
<b>Fixed Cell Suspension:</b> A client-prepared fixed cell suspension is acceptable if received in 3:1 Methanol:Glacial Acetic Acid.</p>
<b>Peripheral Blood:</b> 2-5 mL in sodium heparin tube. EDTA tube is acceptable.<br>
<b>Fresh, Unfixed Tissue:</b> Tissue in RPMI.<br>
<b>Bone Marrow/Peripheral Blood Smear or Fresh Tissue Touch Preparation Slides:</b> Minimum 1 slide, labeled with specimen type.<br>
<b>Fluids:</b> Mix in equal parts with RPMI (specimen volume to RPMI ratio of 1:1).<br>
<b>Fixed Cell Suspension:</b> A client-prepared fixed cell suspension is acceptable if received in 3:1 Methanol:Glacial Acetic Acid.</p>
Flag Active
True
Orderable Test Description
This test uses RARA (17q21) probes to detect gene abnormalities associated with acute promyelocytic leukemia (APL) and acute myeloid leukemia (AML).
Orderable Turn Around Time
3-5 Days
Keywords
Orderable Biomarkers
NY Approved
True
Orderable Biomarkers JSON
{"Fluorescence In Situ Hybridization (FISH)": {"Translocation(s)": ["RARA"]}}
Keywords string
rara, rara break, break apart, FISH, RARA Break-Apart
Title URL
rara-break-apart
Clinical Significance
This RARA break-apart probe is useful for detecting variant RARA translocations with partners other than PML such as t(5;17) and t(11;17). Testing is recommended when FISH for t(15;17) is negative but extra RARA signals are seen to distinguish variant RARA translocations from trisomy 17. If indicated, follow-up metaphase FISH may be added to identify rearrangement partner chromosomes as an aid to therapy selection. Testing is also useful for verifying RARA status when morphology is suspicious for APL but t(15;17) FISH is negative.
TAT Details
STAT (upon request):
12-24 hours from receipt in the NeoGenomics laboratory
Storage and transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. For fresh samples: refrigerate before shipping and ship same day as drawn whenever possible. Do not freeze. NYS clients please provide date and time of collection.