Code
FSH-MDSS-03BX
Panel
Active-Compendium
88374x5 automated. If reflex is added, add 88374x3.
Clinical
Pathology
<p><b>Bone Marrow Aspirate:</b> 1-2 mL in sodium heparin tube. EDTA tube is acceptable.<br>
<b>Peripheral Blood:</b> 2-5 mL in sodium heparin tube. EDTA tube is acceptable.<br>
<b>Fresh, Unfixed Tissue:</b> Tissue in RPMI.<br>
<b>Bone Marrow/Peripheral Blood Smear or Fresh Tissue Touch Preparation Slides:</b> Minimum 4 slides, labeled with specimen type.<br>
<b>Fluids:</b> Mix in equal parts with RPMI (specimen volume to RPMI ratio of 1:1).<br>
<b>Fixed Cell Suspension:</b> A client-prepared fixed cell suspension is acceptable if received in 3:1 Methanol:Glacial Acetic Acid.</p>
<b>Peripheral Blood:</b> 2-5 mL in sodium heparin tube. EDTA tube is acceptable.<br>
<b>Fresh, Unfixed Tissue:</b> Tissue in RPMI.<br>
<b>Bone Marrow/Peripheral Blood Smear or Fresh Tissue Touch Preparation Slides:</b> Minimum 4 slides, labeled with specimen type.<br>
<b>Fluids:</b> Mix in equal parts with RPMI (specimen volume to RPMI ratio of 1:1).<br>
<b>Fixed Cell Suspension:</b> A client-prepared fixed cell suspension is acceptable if received in 3:1 Methanol:Glacial Acetic Acid.</p>
Flag Active
True
Orderable Test Description
<p>This FISH Panel was designed to detect key chromosomal abnormalities associated with myelodysplastic syndrome (MDS). It includes the following probes:<br><br>
5q-, -5 (5p15, 5q31, 5q33)<br>
7q-, -7 (Cen 7, 7q22, 7q31)<br>
Trisomy 8 (Cen 8)<br>
p53 (17p13.1)/NF1 (17q11)<br>
20q- (20q12, 20qter)<br>
RPN1, MECOM (3q21, 3q26.2)<br><br>
Optional Reflex (available with Global cases only):<br>
ETV6 (12p13)<br>
MLL (11q23)<br>
+19 (19p13.2, 19q13)<br>
when the main panel is negative.<br><br>
Test Customization: Probes may be ordered separately except +8 and 20q- which are combined. Reflex results will be reported separately as MDS Standard Reflex Panel.</p>
5q-, -5 (5p15, 5q31, 5q33)<br>
7q-, -7 (Cen 7, 7q22, 7q31)<br>
Trisomy 8 (Cen 8)<br>
p53 (17p13.1)/NF1 (17q11)<br>
20q- (20q12, 20qter)<br>
RPN1, MECOM (3q21, 3q26.2)<br><br>
Optional Reflex (available with Global cases only):<br>
ETV6 (12p13)<br>
MLL (11q23)<br>
+19 (19p13.2, 19q13)<br>
when the main panel is negative.<br><br>
Test Customization: Probes may be ordered separately except +8 and 20q- which are combined. Reflex results will be reported separately as MDS Standard Reflex Panel.</p>
Orderable Turn Around Time
3-5 Days
Keywords
NY Approved
True
Orderable Biomarkers JSON
{"Fluorescence In Situ Hybridization (FISH)": {"Structural Rearrangement(s)": ["MECOM"], "Rearrangement(s)": ["ETV6", "MLL"], "Trisomy": ["Chromosome 8"], "Deletion(s)": ["5q-", "19q", "TP53", "20q", "ETV6", "7q-"]}}
Keywords string
MDS, myelodysplastic syndromes MDS Standard FISH Panel
Title URL
mds-standard-fish-panel
Clinical Significance
The MDS Standard FISH Panel identifies the most frequent cytogenetic abnormalities associated with favorable, intermediate, and poor risk according to IPSS guidelines (since revised). See also the separate listing for MDS Extended FISH Panel which accommodates the 2012 IPSS-Revised classification.
Storage and transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. For fresh samples: refrigerate before shipping and ship same day as drawn whenever possible. Do not freeze. NYS clients please provide date and time of collection.