Code
FSH-MDSE-03BX
Panel
Active-Compendium
88374x8 automated. Codes may differ if manual analysis is performed.
Clinical
Pathology
<p><b>Bone Marrow Aspirate:</b> 1-2 mL in sodium heparin tube. EDTA tube is acceptable.<br>
<b>Peripheral Blood:</b> 2-5 mL in sodium heparin tube. EDTA tube is acceptable.<br>
<b>Fresh, Unfixed Tissue:</b> Tissue in RPMI.<br>
<b>Bone Marrow/Peripheral Blood Smear or Fresh Tissue Touch Preparation Slides:</b> Minimum 8 slides, labeled with specimen type.<br>
<b>Fluids:</b> Mix in equal parts with RPMI (specimen volume to RPMI ratio of 1:1).<br>
<b>Fixed Cell Suspension:</b> A client-prepared fixed cell suspension is acceptable if received in 3:1 Methanol:Glacial Acetic Acid.</p>
<b>Peripheral Blood:</b> 2-5 mL in sodium heparin tube. EDTA tube is acceptable.<br>
<b>Fresh, Unfixed Tissue:</b> Tissue in RPMI.<br>
<b>Bone Marrow/Peripheral Blood Smear or Fresh Tissue Touch Preparation Slides:</b> Minimum 8 slides, labeled with specimen type.<br>
<b>Fluids:</b> Mix in equal parts with RPMI (specimen volume to RPMI ratio of 1:1).<br>
<b>Fixed Cell Suspension:</b> A client-prepared fixed cell suspension is acceptable if received in 3:1 Methanol:Glacial Acetic Acid.</p>
Flag Active
True
Orderable Test Description
<p>The MDS Extended FISH Panel accommodates the 2012 Revised IPSS (IPSS-R) classification of five cytogenetic risk groups: very good, good, intermediate, poor, and very poor. This FISH Panel was designed to detect key chromosomal abnormalities associated with myelodysplastic syndrome (MDS). It includes the following probes:<br><br>
RPN1, MECOM (3q21, 3q26.2)<br>
5q-, -5 (5p15, 5q31, 5q33)<br>
7q-, -7 (Cen 7, 7q22, 7q31)<br>
Trisomy 8 (Cen 8)<br>
MLL (11q23)<br>
ETV6 (12p13)<br>
17p- (TP53 17p13.1, NF1 17q11.2)<br>
+19 (19p13.2, 19q13)<br>
20q- (20q12, 20qter)<br><br>
Test Customization: Probes may be ordered separately, except +8 and 20q-, which are combined.</p>
RPN1, MECOM (3q21, 3q26.2)<br>
5q-, -5 (5p15, 5q31, 5q33)<br>
7q-, -7 (Cen 7, 7q22, 7q31)<br>
Trisomy 8 (Cen 8)<br>
MLL (11q23)<br>
ETV6 (12p13)<br>
17p- (TP53 17p13.1, NF1 17q11.2)<br>
+19 (19p13.2, 19q13)<br>
20q- (20q12, 20qter)<br><br>
Test Customization: Probes may be ordered separately, except +8 and 20q-, which are combined.</p>
Orderable Turn Around Time
3-5 Days
Keywords
Orderable Biomarkers
NY Approved
True
Orderable Biomarkers JSON
{"Fluorescence In Situ Hybridization (FISH)": {"Structural Rearrangement(s)": ["MECOM", "KMT2A"], "Trisomy": ["Chromosome 19", "Chromosome 8"], "Deletion(s)": ["5q-", "7q-", "TP53", "20q", "ETV6"], "Rearrangement(s)": ["ETV6"]}}
Keywords string
MDS, myelodysplastic syndromes MDS Extended FISH Panel
Title URL
mds-extended-fish-panel
Clinical Significance
The MDS Extended FISH Panel accommodates the 2012 Revised IPSS (IPSS-R) classification of five cytogenetic risk groups: very good, good, intermediate, poor, and very poor.
Storage and transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. For fresh samples: refrigerate before shipping and ship same day as drawn whenever possible. Do not freeze. NYS clients please provide date and time of collection.