Code
FSH-IMAB-01BX
Test
Active-Compendium
88374x1 automated. Codes may differ if manual analysis is performed.
Clinical
Pathology
<p><b>Bone Marrow Aspirate:</b> 1-2 mL in sodium heparin tube. EDTA tube is acceptable.<br>
<b>Peripheral Blood:</b> 2-5 mL in sodium heparin tube. EDTA tube is acceptable.<br>
<b>Fresh, Unfixed Tissue:</b> Tissue in RPMI.<br>
<b>Bone Marrow/Peripheral Blood Smear or Fresh Tissue Touch Preparation Slides:</b> Minimum 1 slide, labeled with specimen type.<br>
<b>Fluids:</b> Mix in equal parts with RPMI (specimen volume to RPMI ratio of 1:1).<br>
<b>Fixed Cell Suspension:</b> A client-prepared fixed cell suspension is acceptable if received in 3:1 Methanol:Glacial Acetic Acid.</p>
<b>Peripheral Blood:</b> 2-5 mL in sodium heparin tube. EDTA tube is acceptable.<br>
<b>Fresh, Unfixed Tissue:</b> Tissue in RPMI.<br>
<b>Bone Marrow/Peripheral Blood Smear or Fresh Tissue Touch Preparation Slides:</b> Minimum 1 slide, labeled with specimen type.<br>
<b>Fluids:</b> Mix in equal parts with RPMI (specimen volume to RPMI ratio of 1:1).<br>
<b>Fixed Cell Suspension:</b> A client-prepared fixed cell suspension is acceptable if received in 3:1 Methanol:Glacial Acetic Acid.</p>
Flag Active
True
Orderable Test Description
This test uses IgH/MAFB t(14;20) probes to detect gene rearrangements associated with myeloma and monoclonal gammopathy of undetermined significance (MGUS). This probe combination may be ordered separately or added to myeloma FISH panels.
Orderable Turn Around Time
3-5 Days
Keywords
Orderable Biomarkers
NY Approved
True
Orderable Biomarkers JSON
{"Fluorescence In Situ Hybridization (FISH)": {"Translocation(s)": ["MAFB/IgH t(14;20)"]}}
Keywords string
multiple myeloma, MGUS IgH/MAFB t(14;20)
Title URL
igh-mafb-t14-20
Clinical Significance
The translocation (14;20) is rare in multiple myeloma (MM) but associated with a poor prognosis for that diagnosis. In contrast, t(14;20) in patients with MGUS is associated with a long-term stable disease.
Storage and transportation
Refrigerate specimen. Do not freeze. Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of collection.