Code
FSH-IGLM-01BX
Test
Active-Compendium
88374x1 automated or 88377x1 manual
Clinical
Pathology
<p><b>Bone Marrow Aspirate:</b> 1-2 mL in sodium heparin tube. EDTA tube is acceptable.<br>
<b>Peripheral Blood:</b> 2-5 mL in sodium heparin tube. EDTA tube is acceptable.<br>
<b>Fresh, Unfixed Tissue:</b> Tissue in RPMI.<br>
<b>Bone Marrow/Peripheral Blood Smear or Fresh Tissue Touch Preparation Slides:</b> Minimum 1 slide, labeled with specimen type.<br>
<b>Fluids:</b> Mix in equal parts with RPMI (specimen volume to RPMI ratio of 1:1).<br>
<b>Fixed Cell Suspension:</b> A client-prepared fixed cell suspension is acceptable if received in 3:1 Methanol:Glacial Acetic Acid.<br>
<b>H&E slide (required) plus paraffin block.</b><br>
<b>Cut Slides:</b> H&E slide (required) plus 3 unstained slides cut at 4-5 microns.<br>
<b>Note for Tech Only clients:</b> Please circle H&E slide.</p>
<b>Peripheral Blood:</b> 2-5 mL in sodium heparin tube. EDTA tube is acceptable.<br>
<b>Fresh, Unfixed Tissue:</b> Tissue in RPMI.<br>
<b>Bone Marrow/Peripheral Blood Smear or Fresh Tissue Touch Preparation Slides:</b> Minimum 1 slide, labeled with specimen type.<br>
<b>Fluids:</b> Mix in equal parts with RPMI (specimen volume to RPMI ratio of 1:1).<br>
<b>Fixed Cell Suspension:</b> A client-prepared fixed cell suspension is acceptable if received in 3:1 Methanol:Glacial Acetic Acid.<br>
<b>H&E slide (required) plus paraffin block.</b><br>
<b>Cut Slides:</b> H&E slide (required) plus 3 unstained slides cut at 4-5 microns.<br>
<b>Note for Tech Only clients:</b> Please circle H&E slide.</p>
Flag Active
True
Orderable Test Description
This test uses IGL/MYC t(8;22) probes to detect gene rearrangements associated with B-cell lymphoma, double-hit lymphoma, and triple-hit lymphoma.
Orderable Turn Around Time
3-5 Days
Keywords
Orderable Biomarkers
NY Approved
True
Orderable Biomarkers JSON
{"Fluorescence In Situ Hybridization (FISH)": {"Translocation(s)": ["IGK/MYC t(2;8)"]}}
Keywords string
MYC translocation, IGL translocation, lymphoma IGL/MYC t(8;22) translocation
Title URL
igl-myc-t8-22-translocation
Clinical Significance
IGL/MYC translocation is observed recurrently in B-cell lymphomas, and when occurred concurrently with BCL2 and/or BCL6 rearrangement, is classified as double-hit/triple-hit lymphomas having a very poor prognosis.
Storage and transportation
Refrigerate specimen. Do not freeze. Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of collection.