High-Grade B-Cell Lymphoma with 11q Aberration (formerly 11q Aberration in NHL)

Code

FSH-ELNH-01BX

Test

Active-Compendium

88374x1 automated or 88377x1 manual

Clinical

Pathology

H&E slide (required) plus paraffin block. 
Cut Slides: H&E slide (required) plus 3 unstained slides cut at 4-5 microns. 
Note for Tech Only clients: Please circle H&E slide.

Hematologic Diseases

Burkitt lymphoma

Diffuse large B-cell lymphoma (DLBCL)

Non-Hodgkin lymphoma (NHL)

Mon, 01/13/2025 - 12:00

Fri, 02/06/2026 - 12:00

FISH

Global

Tech Only

Flag Active

True

Orderable Test Description

This test uses CEN 11 (11p11.1-q11), MLL (11q23), and 11qTel (11q25) probes to detect gene abnormalities associated with high-grade B-cell lymphoma.

Orderable Turn Around Time

3-5 Days

Keywords

11q abnormality

Meta Description

This FISH panel detects proximal gains and distal losses of chromosome 11q which are recurrent abnormalities in MYC-negative high grade B-cell lymphomas resembling Burkitt lymphoma. Burkitt-like lymphoma with 11q aberration was recognized by the WHO in 2017 as a new provisional entity.

Orderable Biomarkers

11q

NY Approved

True

Orderable Biomarkers JSON

{"Fluorescence In Situ Hybridization (FISH)": {"Rearrangement": ["11q"]}}

Keywords string

11q abnormality High-Grade B-Cell Lymphoma with 11q Aberration (formerly 11q Aberration in NHL)

Title URL

high-grade-b-cell-lymphoma-with-11q-aberration-formerly-11q-aberration-in-nhl

Clinical Significance

This FISH panel is designed to detect the recurrent proximal gains and distal losses of chromosome 11q which define MYC-negative high grade B-cell lymphoma with 11q aberration in WHO-HAEM5 and in the ICC-2022 (provisional).

Storage and transportation

Refrigerate specimen. Do not freeze. Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of collection.