Code
FSH-CLLF-03BX
Panel
Active-Compendium
88374x4 automated. Codes may differ if manual analysis is performed.
Clinical
Pathology
<p><b>Bone Marrow Aspirate:</b> 1-2 mL in sodium heparin tube. EDTA tube is acceptable.<br>
<b>Peripheral Blood:</b> 2-5 mL in sodium heparin tube. EDTA tube is acceptable.<br>
<b>Fresh, Unfixed Tissue:</b> Tissue in RPMI.<br>
<b>Bone Marrow/Peripheral Blood Smear or Fresh Tissue Touch Preparation Slides:</b> Minimum 4 slides, labeled with specimen type.<br>
<b>Fluids:</b> Mix in equal parts with RPMI (specimen volume to RPMI ratio of 1:1).<br>
<b>Fixed Cell Suspension:</b> A client-prepared fixed cell suspension is acceptable if received in 3:1 Methanol:Glacial Acetic Acid.<br>
<b>H&E slide (required) plus paraffin block.</b><br>
<b>Cut Slides:</b> H&E slide (required) plus 6 unstained slides cut at 4-5 microns.<br>
<b>Note for Tech Only clients:</b> Please circle H&E slide.<br>
<b>Note for NYS clients:</b> Cut slides and paraffin block specimens are not accepted.</p>
<b>Peripheral Blood:</b> 2-5 mL in sodium heparin tube. EDTA tube is acceptable.<br>
<b>Fresh, Unfixed Tissue:</b> Tissue in RPMI.<br>
<b>Bone Marrow/Peripheral Blood Smear or Fresh Tissue Touch Preparation Slides:</b> Minimum 4 slides, labeled with specimen type.<br>
<b>Fluids:</b> Mix in equal parts with RPMI (specimen volume to RPMI ratio of 1:1).<br>
<b>Fixed Cell Suspension:</b> A client-prepared fixed cell suspension is acceptable if received in 3:1 Methanol:Glacial Acetic Acid.<br>
<b>H&E slide (required) plus paraffin block.</b><br>
<b>Cut Slides:</b> H&E slide (required) plus 6 unstained slides cut at 4-5 microns.<br>
<b>Note for Tech Only clients:</b> Please circle H&E slide.<br>
<b>Note for NYS clients:</b> Cut slides and paraffin block specimens are not accepted.</p>
Flag Active
True
Orderable Test Description
<p>The CLL FISH panel is used for the detection of chromosome aberrations observed in chronic lymphocytic leukemia/small lymphocytic lymphoma, which are useful in prognosis and prediction of time to treatment in CLL patients when used in combination with other clinical and diagnostic findings. This FISH Panel is designed to detect common cytogenetic abnormalities associated with CLL, which can provide valuable prognostic information. This panel includes the following probes:<br><br>
6q- [SEC63 (6q21), MYB (6q23)]<br>
ATM (11q22.3)<br>
p53 (17p13.1)<br>
Trisomy 12 (Cen 12)<br>
13q-/-13 (13q14, 13q34)<br>
CCND1/IgH t(11;14)<br><br>
Test Customization: Probes may be ordered separately, except for probes for 12 and 13q are tested together, and ATM is tested with p53).</p>
6q- [SEC63 (6q21), MYB (6q23)]<br>
ATM (11q22.3)<br>
p53 (17p13.1)<br>
Trisomy 12 (Cen 12)<br>
13q-/-13 (13q14, 13q34)<br>
CCND1/IgH t(11;14)<br><br>
Test Customization: Probes may be ordered separately, except for probes for 12 and 13q are tested together, and ATM is tested with p53).</p>
Orderable Turn Around Time
3-5 Days
Keywords
Orderable Biomarkers
NY Approved
True
Orderable Biomarkers JSON
{"Fluorescence In Situ Hybridization (FISH)": {"Trisomy": ["Chromosome 12"], "Deletion(s)": ["13q", "TP53", "ATM", "6q-"], "Translocation(s)": ["CCND1(BCL1)/IgH t(11;14)"]}}
Keywords string
myb, my b, myb 6q23, 6q23, my, cll, cll fish, cll fish non, cll fish non new york, cll fish ny, cll fish non ny, MYB, TP53 CLL FISH Panel
Title URL
cll-fish-panel
Clinical Significance
The CLL FISH panel is used for the detection of chromosome aberrations observed in chronic lymphocytic leukemia/small lymphocytic lymphoma, which are useful in prognosis and prediction of time to treatment in CLL patients when used in combination with other clinical and diagnostic findings. CCND1/IgH is used to rule out mantle cell leukemia/lymphoma.
Storage and transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. For fresh samples: refrigerate before shipping and ship same day as drawn whenever possible. Do not freeze. NYS clients please provide date and time of collection.