Code
FSH-AMLS-03BX
Panel
Active-Compendium
88374x5 automated. If reflex is added, add 88374x5.
Clinical
Pathology
<p><b>Bone Marrow Aspirate:</b> 1-2 mL in sodium heparin tube. EDTA tube is acceptable.<br>
<b>Peripheral Blood:</b> 2-5 mL in sodium heparin tube. EDTA tube is acceptable.<br>
<b>Fresh, Unfixed Tissue:</b> Tissue in RPMI.<br>
<b>Bone Marrow/Peripheral Blood Smear or Fresh Tissue Touch Preparation Slides:</b> Minimum 7 slides, labeled with specimen type.<br>
<b>Fluids:</b> Mix in equal parts with RPMI (specimen volume to RPMI ratio of 1:1).<br>
<b>Fixed Cell Suspension:</b> A client-prepared fixed cell suspension is acceptable if received in 3:1 Methanol:Glacial Acetic Acid.</p>
<b>Peripheral Blood:</b> 2-5 mL in sodium heparin tube. EDTA tube is acceptable.<br>
<b>Fresh, Unfixed Tissue:</b> Tissue in RPMI.<br>
<b>Bone Marrow/Peripheral Blood Smear or Fresh Tissue Touch Preparation Slides:</b> Minimum 7 slides, labeled with specimen type.<br>
<b>Fluids:</b> Mix in equal parts with RPMI (specimen volume to RPMI ratio of 1:1).<br>
<b>Fixed Cell Suspension:</b> A client-prepared fixed cell suspension is acceptable if received in 3:1 Methanol:Glacial Acetic Acid.</p>
Flag Active
True
Orderable Test Description
<p>This panel is designed for the detection of genetic abnormalities commonly associated with acute myeloid leukemia (AML). It includes the following probes:<br><br>
CBFB inv(16), t(6;16)<br>
KMT2A (MLL) (11q23)<br>
PML/RARA t(15;17)<br>
RUNX1/RUNX1T1 (ETO/AML1) t(8;21)<br>
RPN1, MECOM (3q21, 3q26.2)<br>
Optional Reflex (available with Global cases only):<br><br>
5q-, -5 (5p15, 5q31, 5q33)<br>
7q-, -7 (Cen 7, 7q22, 7q31)<br>
DEK/NUP214 (CAN) t(6;9)<br>
p53 (17p13.1)/NF1 (17q11)<br>
NUP98 (11p15) when the main panel is negative.<br><br>
Test Customization: Probes may be ordered separately. Results will be reported separately as AML Standard Reflex Panel.<br><br>
STAT Processing (upon request): Available for PML/RARA t(15;17). Include "STAT" along with the requesting physician's name and contact information for expedited results.</p>
CBFB inv(16), t(6;16)<br>
KMT2A (MLL) (11q23)<br>
PML/RARA t(15;17)<br>
RUNX1/RUNX1T1 (ETO/AML1) t(8;21)<br>
RPN1, MECOM (3q21, 3q26.2)<br>
Optional Reflex (available with Global cases only):<br><br>
5q-, -5 (5p15, 5q31, 5q33)<br>
7q-, -7 (Cen 7, 7q22, 7q31)<br>
DEK/NUP214 (CAN) t(6;9)<br>
p53 (17p13.1)/NF1 (17q11)<br>
NUP98 (11p15) when the main panel is negative.<br><br>
Test Customization: Probes may be ordered separately. Results will be reported separately as AML Standard Reflex Panel.<br><br>
STAT Processing (upon request): Available for PML/RARA t(15;17). Include "STAT" along with the requesting physician's name and contact information for expedited results.</p>
Orderable Turn Around Time
3-5 Days
Keywords
Orderable Biomarkers
NY Approved
True
Orderable Biomarkers JSON
{"Fluorescence In Situ Hybridization (FISH)": {"Translocation(s)": ["RUNX1T1/RUNX1 (ETO/AML1) t(8;21)", "PML/RARA t(15;17)"], "Structural Rearrangement(s)": ["MECOM", "KMT2A", "NUP98", "NUP214"], "Deletion(s)": ["5q-", "TP53", "7q-"], "Inversion(s)": ["CBFB inv(16), t(16;16)"]}}
Keywords string
AML, acute myeloid leukemia AML Standard FISH Panel
Title URL
aml-standard-fish-panel
Clinical Significance
The AML Standard FISH Panel identifies the most frequent cytogenetic abnormalities associated with favorable, intermediate, and poor risk. See also the AML Non-Favorable Risk Panel and the AML Favorable-Risk Panel.
TAT Details
STAT PML-RARA (upon request):
12-24 hours from receipt in the NeoGenomics laboratory
12-24 hours from receipt in the NeoGenomics laboratory
Storage and transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. For fresh samples: refrigerate before shipping and ship same day as drawn whenever possible. Do not freeze. NYS clients please provide date and time of collection.