Code
FSH-ALLH-03BX
Panel
Active-Compendium
88374x5 automated or 88377x5 manual. Codes may differ if manual analysis is performed.
Clinical
Pathology
<p><b>Bone Marrow Aspirate:</b> 1-2 mL in sodium heparin tube. EDTA tube is acceptable.<br>
<b>Peripheral Blood:</b> 2-5 mL in sodium heparin tube. EDTA tube is acceptable.<br>
<b>Fresh, Unfixed Tissue:</b> Tissue in RPMI.<br>
<b>Bone Marrow/Peripheral Blood Smear or Fresh Tissue Touch Preparation Slides:</b> Minimum 5 slides, labeled with specimen type.<br>
<b>Fluids:</b> Mix in equal parts with RPMI (specimen volume to RPMI ratio of 1:1).<br>
<b>Fixed Cell Suspension:</b> A client-prepared fixed cell suspension is acceptable if received in 3:1 Methanol:Glacial Acetic Acid.</p>
<b>Peripheral Blood:</b> 2-5 mL in sodium heparin tube. EDTA tube is acceptable.<br>
<b>Fresh, Unfixed Tissue:</b> Tissue in RPMI.<br>
<b>Bone Marrow/Peripheral Blood Smear or Fresh Tissue Touch Preparation Slides:</b> Minimum 5 slides, labeled with specimen type.<br>
<b>Fluids:</b> Mix in equal parts with RPMI (specimen volume to RPMI ratio of 1:1).<br>
<b>Fixed Cell Suspension:</b> A client-prepared fixed cell suspension is acceptable if received in 3:1 Methanol:Glacial Acetic Acid.</p>
Flag Active
True
Orderable Test Description
<p>This FISH panel was designed to detect genetic abnormalities associated with Philadelphia chromosome-like (Ph-like) acute lymphoblastic leukemia (ALL) and B lymphoblastic leukemia/lymphoma (LBL). It includes the following probes:<br><br>
PDGFRb (5q32)<br>
BCR/ABL1-ASS1 t(9;22)<br>
JAK2 (9p24.1)<br>
EPOR (19p13.2)<br>
CRLF2 (Xp22.33/Yp11.32)<br><br>
Test Customization: Probes may be ordered separately.<br><br>
STAT Processing (upon request): Available for BCR/ABL1/ASS1 t(9;22). Include "STAT" along with the requesting physician's name and contact information for expedited results.</p>
PDGFRb (5q32)<br>
BCR/ABL1-ASS1 t(9;22)<br>
JAK2 (9p24.1)<br>
EPOR (19p13.2)<br>
CRLF2 (Xp22.33/Yp11.32)<br><br>
Test Customization: Probes may be ordered separately.<br><br>
STAT Processing (upon request): Available for BCR/ABL1/ASS1 t(9;22). Include "STAT" along with the requesting physician's name and contact information for expedited results.</p>
Orderable Turn Around Time
3-5 Days
Orderable Biomarkers
NY Approved
True
Orderable Biomarkers JSON
{"Fluorescence In Situ Hybridization (FISH)": {"Rearrangement(s)": ["EPOR", "CRLF2", "PDGFRB"], "Structural Rearrangement(s)": ["JAK2"], "Translocation(s)": ["BCR/ABL1/ASS1 t(9;22)"]}}
Keywords string
Philadelphia chromosome ALL flow, Ph-like ALL flow, ALL ALL FISH Panel (Ph-Like)
Title URL
all-fish-panel-ph-like
Clinical Significance
The ALL FISH Panel (Ph-like) detects cytogenetic abnormalities commonly associated with Philadelphia chromosome (Ph-like) acute lymphoblastic leukemia (ALL). Patients with Ph-like B-ALL are associated with an unfavorable prognosis, but may potentially be amenable to inhibition with select tyrosine kinase inhibitors.
Storage and transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. For fresh samples: refrigerate before shipping and ship same day as drawn whenever possible. Do not freeze. NYS clients please provide date and time of collection.