Code
FSH-HGBC-03BX
Panel
Active-Compendium
88374x4 automated. If reflex is added, add 88374x3. Codes may differ if manual analysis is performed.
Clinical
Pathology
Bone marrow aspirate: 1-2 mL sodium heparin tube. EDTA tube is acceptable.
Peripheral blood: 2-5 mL sodium heparin tube. EDTA tube is acceptable.
Fresh, unfixed tissue: Tissue in RPMI.
Bone Marrow/ Peripheral Blood Smear or Fresh Tissue Touch Preparation Slides: minimum *3-5 slides* labeled with specimen type.
NOTE: 3 slides needed for base 3 probe panel, 1 slide needed if optional 14;18 added, 1 slide needed if optional 8;14 added
Fluids: Equal parts RPMI to specimen volume
Fixed Cell Suspension: A client fixed cell suspension may be submitted for testing as long as it is received in 3:1 Methanol:Glacial Acetic Acid.
Paraffin block: H&E slide (required) plus paraffin block. Circle H&E for tech-only.
Cut slides: H&E slide (required) plus 8 unstained slides cut at 4 microns. Circle H&E for tech-only.
Note: Please exclude biopsy needles, blades, and other foreign objects from transport tubes. These can compromise specimen viability and yield, and create hazards for employees.
Peripheral blood: 2-5 mL sodium heparin tube. EDTA tube is acceptable.
Fresh, unfixed tissue: Tissue in RPMI.
Bone Marrow/ Peripheral Blood Smear or Fresh Tissue Touch Preparation Slides: minimum *3-5 slides* labeled with specimen type.
NOTE: 3 slides needed for base 3 probe panel, 1 slide needed if optional 14;18 added, 1 slide needed if optional 8;14 added
Fluids: Equal parts RPMI to specimen volume
Fixed Cell Suspension: A client fixed cell suspension may be submitted for testing as long as it is received in 3:1 Methanol:Glacial Acetic Acid.
Paraffin block: H&E slide (required) plus paraffin block. Circle H&E for tech-only.
Cut slides: H&E slide (required) plus 8 unstained slides cut at 4 microns. Circle H&E for tech-only.
Note: Please exclude biopsy needles, blades, and other foreign objects from transport tubes. These can compromise specimen viability and yield, and create hazards for employees.
Flag Active
True
Orderable Test Description
Probes: BCL6 (3q27) | MYC (8q24) | BCL2 (18q21) | MYC/IgH/CEN8 t(8;14)
Optional Reflex: IGK/MYC t(2;8) | IGL/MYC t(8;22) | BCL6/MYC t(3;8), if MYC (8q24) is positive and MYC/IgH/CEN8 t(8;14) is negative
Disease(s): B-cell lymphoma, double-hit lymphoma, triple-hit lymphoma
Optional Reflex: IGK/MYC t(2;8) | IGL/MYC t(8;22) | BCL6/MYC t(3;8), if MYC (8q24) is positive and MYC/IgH/CEN8 t(8;14) is negative
Disease(s): B-cell lymphoma, double-hit lymphoma, triple-hit lymphoma
Orderable Turn Around Time
3-5 Days for both unfixed and FFPE specimens
Extra Note
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.
NY Approved
True
Orderable Biomarkers JSON
{"Fluorescence In Situ Hybridization (FISH)": {"Rearrangement(s)": ["MYC-IgH"], "Amplification(s)": ["MYC"], "Structural Rearrangement(s)": ["BCL6", "BCL2"]}}
Keywords string
Large B-cell Lymphoma, BCL2, BCL6, Burkitt lymphoma, diffuse large B-cell lymphoma. High-Grade/Large B-Cell Lymphoma Panel (NY and non-NY)
Title URL
high-grade-large-b-cell-lymphoma-panel-ny-and-non-ny