Code
APT-CDBX-01AX
Test
Active-Compendium
88342 x 1 or 88341 x 1
Clinical
Pathology
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen type or one (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody ordered.
Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Flag Active
True
Orderable Test Description
<p>CD117 (cKit) is a transmembrane receptor tyrosine kinase. It is expressed in many tissues and cells, such as tissue mast cells, skin basal cells, melanocytes, breast glandular epithelial cells, dermal sweat gland, esophageal glands, testicular and ovarian interstitial cells. Abnormal expression of cKit has been implicated in pathogenesis of myeloid leukemias. cKit expression has also been demonstrated in solid tumors including gastrointestinal stromal tumor (GIST), melanomas, breast carcinomas and small cell lung carcinoma. C-Kit pharmDXTM is indicated as an aid in the differential diagnosis of GIST. Accurate assessment of CD117 protein expression using cKIT testing is a critical factor in the diagnosis of GIST and is becoming increasingly important in clinical management, including the use of imatinib mesylate (Gleevec®) therapy.</p>
Orderable Turn Around Time
Tech-Only (stain only): 1 Day
Keywords
Extra Note
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.
Orderable Biomarkers
NY Approved
True
Orderable Biomarkers JSON
{"Immunohistochemistry (IHC)": {"Expression": ["CD117 cKIT"]}}
Keywords string
CD117, cKIT, KIT expression, KIT IHC CD117 cKIT
Title URL
cd117-ckit